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Introducing Product

Januluma is a combination cream containing 4% hydroquinone, 0.05% tretinoin and 0.01% fluosinolone acetonide, which was produced for the first time in Iran by Janus Pharma and is used to treat moderate to severe dark facial melasma spots. Placed. Januluma has receive the Knowledge-Based Award from the Vice President Office for Science and Technology.

Melasma is an acquired disease, characterized by brown to dark gray spots (hyperpigmentation) that appear on parts of the facial skin that are most exposed to the sun, especially on the cheeks, , forehead and chin.

:Directions

Januluma should be used for 8 weeks; however, this period may be increased or decreased based on the attending physician.

The dose of each medicine is determined by the physician; but usually the amount and method of using Januluma cream is as follows:

First, cleanse your face with a mild cleanser. Apply a thin layer of cream on the affected area every night for half an hour before going to bed. Do not cover or use dressing on the area after applying Januluma cream. After waking up, wash your face with a mild cleanser and use a suitable sunscreen and moisturizer.

In case of very sensitive skin, as advised by the physician, the face can be washed at night, maximum 3 hours after applying Januluma cream, with water and mild cleanser so not keeping the cream on skin overnight. In certain occasions, some doctors prefer to start taking Januluma every other night and then use it every night for up to eight weeks.

After use of Januluma cream wash your hands.

:Mechanism

The combination of three active ingredients in Januluma cream has made it one of the best and most effective topical medicines in curing melasma spots:

Hydroquinone, a hydroxyphenol, inhibits melanin buildup by inhibiting tyrosinase; it also increases melanin excretion from melanocytes. This substance is the main golden composition for skin brightening, with an added-value efficiency in Januluma specific formulation.

Tretinoin is classified as a keratolytic drug and is a vitamin A metabolite. By stimulating the proliferation process, tretinoin increases epidermal cell mitotic and cell cycle of epidermal tissue. This process, along with weakening the cell layer, results in less cohesion and easier peeling. Tretinoin also inhibits melanin synthesis in melanocytes, reduces the amount of melanin and brightens the skin. Tretenoin also increases the permeability of hydroquinone and flucinolone to skin tissue.

Flucinolone acetonide is a specialized skin corticosteroid with the highest penetration and effect on skin tissue due to its molecular structure. This combination reduces the probable inflammation caused by the tretinoin and hydroquinone. However, some scientific references have mentioned its direct effect on inhibiting melanin synthesis.

Key points

Januluma cream is forbidden during pregnancy and lactation. Consult your doctor if you are expecting to get pregnant during treatment.
Take the medicine as prescribed by your doctor and at regular intervals. Do not exceed the amount prescribed. Overdose may result in redness, scaling, or discomfort.
Januluma may change the skin discoloration. If you notice any bluish discoloration on the skin, stop taking the medicine and consult your doctor.
Unbalanced weather, such as extreme heat or cold, may be irritating for patients under Januluma treatment.
This medicine is for topical use only; so in case of irritation in the affected area, stop taking the medicine. See your doctor if you have blisters, scaling, or severe burning or swelling of the skin and irritation of the mucous membranes of eyes, nose, mouth, and tongue.
Do not apply this cream in and around eyes, nose, mouth, genitals, cuts and/or skin damage parts.
Since Januluma penetrates skin, overdose may cause damage to the adrenal glands.
Avoid prolonged exposure to sunlight, florescent or ultraviolet light. Patients who are constantly exposed to the sun due to working conditions should use a sunscreen of minimum SPF30 with adequate UVA protection. Use protective cover (such as a hat).
Concurrent use of this drug with other topical drugs, entailing severe skin dryness effects, should be avoided.
Avoid taking this drug with topical medications containing high alcohol concentration, other astringents and irritants or exfoliating medications during treatment with this cream.
Januluma cream interacts with drugs that increase photosensitivity in the skin.
People suffering from asthma should avoid this cream because of its sodium metasulfite.
About 10% - 40% of patients who use the cream for treatment of melasma experience complications such as erythema, scaling, burns, dryness and itching; and in 1% - 5% of patients, acne, tingling, dilated capillaries, severe allergies, pigmentation changes, allergies, papules, rosacea, dry mouth and vesicles are observed.
Store refrigerated at 2 - 8 °C and protect from freezing.

Frequently Asked Questions

Can Januluma cream be used in cases other than blemishes on the face, on the hands, elbows and feet, to remove scars and burns on the body, to remove the dullness on bikini, genital and armpits area, to remove age spots on hands?

Januluma cream is also effective for lightening and removing spots on hands, feet, elbows, scars and burns. But it has no effect on stains resulting from the aging process or darkening of the genital and bikini area. In the case of dark underarms, considering the exfoliation and inflammation that occurs when using Januluma, and considering that underarm skin is prone to injury and scarring due to sweating conditions, it is better not to use it.

What is the best guideline to control the side effects, such as redness, itching, dryness and scaling while taking the drug?

These cases are among the side effects of the active ingredients in Januluma cream. To reduce side effects such as dryness, skin peeling and itching, it is better to use a moisturizing and hydrating cream and a mild detergent and sunscreen with at least SPF 30 and with sufficient protection against UVA.

People who have skin redness after using the cream every night, can reduce the use of the drug to every other night.

What sunscreen and moisturizer do you recommend while using Januluma for blemishes?

Sunscreen with SPF higher than 30, with adequate protection against UVA and preferably colorless should be used. Moisturizers and moisturizers suitable for sensitive skin should also be used. Using sunscreen is one of the essential aspects of Melasma treatment.

Januluma cream should not be used in active acnes. In addition, tretinoin is one of the active ingredients of januluma, so it should not be used simultaneously with those anti-acne compounds.

What is the indications of Januluma cream, usage period and maintaining treatment?

The treatment period with Januluma cream is 8 weeks every night, and after the completion of the treatment period, it is recommended twice a week as a maintenance treatment.

How to use: First, clean the face or stained area and apply a thin layer of cream on the desired area half an hour before going to bed. In the morning, wash your face with a mild cleanser and use a suitable sunscreen and moisturizer. In situations where people’s skin is very sensitive, according to the doctor’s opinion, you can wash your face with water and mild cleanser at night for a maximum of 3 hours after using Januluma cream so that the medicine does not remain on the skin until morning. Sometimes, some doctors prefer to start using Januluma every other night and then use it every night for up to eight weeks.

Explain how to refrigerate Januluma, the problem of oxidation at room temperature and how to detect it.

Januluma cream should be stored in a refrigerator at a temperature of 2 to 8 degrees Celsius. If by mistake the cream stays at room temperature for a while, if no color change is observed in the cream, the product is not oxidized and can be consumed. If a dark color change is observed in the product or the consistency of the cream changes, it should not be used. Moving Januluma in about 2 hours from the pharmacy to home or on a city trip will not destroy it, and there is no need to use ice.

Is it allowed to use Januluma cream at the age of puberty?

If it is used for an area that does not have an active acne, it is safe to use.

Is it allowed to use Januluma cream in pregnant or lactating women?

No. It is forbidden to use Januluma cream during pregnancy and breastfeeding.

Can I sunbathe or use a solarium to tan my skin during treatment with Januluma cream?

During treatment, exposure to sunlight, solar lamp, ultraviolet light, and tanning of the treated area should be avoided. Patients who are constantly exposed to sunlight due to work conditions should use sunscreen and protective covering (such as a hat).

Can I use devices such as lasers for my face during treatment with Januluma cream?

Due to the exfoliating properties of this drug, which may cause thinning and inflammation of the treated skin, it is better to stop using the drug for at least a week and then use laser methods.

What should I do if the medicine comes in contact with my lips and mouth?

Clean the affected area with a tissue and rinse the residue with good water. Do not try to remove the medicine with the tongue or by swallowing.

What should I do if the medicine gets in the eyes?

Accidental contact of Januluma cream with the eye causes inflammation and moderate itching. After contact with the eyes, do not rub the eyes and immediately wash the eyes with plenty of water for at least 15 minutes. While washing, open and close the eyes several times to ensure sufficient washing. See a doctor if eye inflammation persists.

What should I do if the medicine is swallowed by the patient?

If the medicine is swallowed by the patient, a large amount of water or milk should be fed to him immediately to dilute the amount of active ingredients. Then go to the hospital immediately. Do not induce vomiting in any way.

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